Ontology highlight
ABSTRACT:
SUBMITTER: Arun G
PROVIDER: S-EPMC5840027 | biostudies-literature | 2018 Mar
REPOSITORIES: biostudies-literature
Arun Gayatri G Diermeier Sarah D SD Spector David L DL
Trends in molecular medicine 20180212 3
Long non-coding RNAs (lncRNAs) represent a significant population of the human transcriptome. Many lncRNAs exhibit cell- and/or tissue/tumor-specific expression, making them excellent candidates for therapeutic applications. In this review we discuss examples of lncRNAs that demonstrate the diversity of their function in various cancer types. We also discuss recent advances in nucleic acid drug development with a focus on oligonucleotide-based therapies as a novel approach to inhibit tumor progr ...[more]