Ontology highlight
ABSTRACT:
SUBMITTER: Kasinath V
PROVIDER: S-EPMC5840869 | biostudies-literature | 2018 Feb
REPOSITORIES: biostudies-literature
Kasinath Vignesh V Faini Marco M Poepsel Simon S Reif Dvir D Feng Xinyu Ashlee XA Stjepanovic Goran G Aebersold Ruedi R Nogales Eva E
Science (New York, N.Y.) 20180118 6378
Transcriptionally repressive histone H3 lysine 27 methylation by Polycomb repressive complex 2 (PRC2) is essential for cellular differentiation and development. Here we report cryo-electron microscopy structures of human PRC2 in a basal state and two distinct active states while in complex with its cofactors JARID2 and AEBP2. Both cofactors mimic the binding of histone H3 tails. JARID2, methylated by PRC2, mimics a methylated H3 tail to stimulate PRC2 activity, whereas AEBP2 interacts with the R ...[more]