Ontology highlight
ABSTRACT:
SUBMITTER: Byun B
PROVIDER: S-EPMC5841429 | biostudies-literature | 2018 Mar
REPOSITORIES: biostudies-literature
Byun Byungjin B Mahasenan Kiran V KV Dik David A DA Marous Daniel R DR Speri Enrico E Kumarasiri Malika M Fisher Jed F JF Hermoso Juan A JA Mobashery Shahriar S
Scientific reports 20180307 1
Lytic transglycosylases (LTs) catalyze the non-hydrolytic cleavage of the bacterial cell wall by an intramolecular transacetalization reaction. This reaction is critically and broadly important in modifications of the bacterial cell wall in the course of its biosynthesis, recycling, manifestation of virulence, insertion of structural entities such as the flagellum and the pili, among others. The first QM/MM analysis of the mechanism of reaction of an LT, that for the Escherichia coli MltE, is un ...[more]