Unknown

Dataset Information

0

Four common polymorphisms of BRIP1 (rs2048718, rs4988344, rs4986764, and rs6504074) and cancer risk: evidence from 13,716 cancer patients and 15,590 cancer-free controls.

ABSTRACT: Previous studies have showed the associations between various BRCA1-interacting protein 1 (BRIP1) polymorphisms and cancer risk. But, these results were inconsistent. This meta-analysis based on 18 studies involving 13,716 cancer patients and 15,590 cancer-free controls is aimed at to evaluate the relationship between the four common SNPs of BRIP1 (rs2048718, rs4988344, rs4986764, and rs6504074) and cancer risk. The results showed a decreased risk of rs2048718 or rs4986764 for cervical cancer rather than breast cancer in the overall population (P < 0.05). However, rs6504074 was associated with gynecologic cancer risk among overall population (P < 0.05). Further stratification analyses by ethnicity indicated that all 4 polymorphisms (rs2048718, rs4988344, rs4986764, and rs6504074) were strongly related to cancer susceptibility in Chinese people (P < 0.05). This meta-analysis showed that rs6504074 may play a decreased risk of gynecologic cancer in the overall population. Rs4988344, rs4986764, and rs6504074 were significantly related to decreasing cancer risk in Chinese population.

SUBMITTER: Liu D 

PROVIDER: S-EPMC5842853 | biostudies-literature | 2018 Feb

REPOSITORIES: biostudies-literature

Json Xml
altmetric image

Publications

Four common polymorphisms of BRIP1 (rs2048718, rs4988344, rs4986764, and rs6504074) and cancer risk: evidence from 13,716 cancer patients and 15,590 cancer-free controls.

Liu Di D   Zheng Yi Y   Wang Meng M   Deng Yujiao Y   Lin Shuai S   Zhou Linghui L   Yang Pengtao P   Dai Cong C   Xu Peng P   Hao Qian Q   Song Dingli D   Kang Huafeng H   Dai Zhijun Z  

Aging 20180201 2

Previous studies have showed the associations between various BRCA1-interacting protein 1 (<i>BRIP1</i>) polymorphisms and cancer risk. But, these results were inconsistent. This meta-analysis based on 18 studies involving 13,716 cancer patients and 15,590 cancer-free controls is aimed at to evaluate the relationship between the four common SNPs of <i>BRIP1</i> (rs2048718, rs4988344, rs4986764, and rs6504074) and cancer risk. The results showed a decreased risk of rs2048718 or rs4986764 for cerv  ...[more]

Similar Datasets

Unknown Pooling-analysis on hMLH1 polymorphisms and cancer risk: evidence based on 31,484 cancer cases and 45,494 cancer-free controls.
| S-EPMC5696244 | biostudies-literature
Unknown The relationship between RAGE gene four common polymorphisms and breast cancer risk in northeastern Han Chinese.
| S-EPMC5394748 | biostudies-literature
Unknown Two common functional catalase gene polymorphisms (rs1001179 and rs794316) and cancer susceptibility: evidence from 14,942 cancer cases and 43,285 controls.
| S-EPMC5325339 | biostudies-literature
Unknown Current evidence on the relationship between two common polymorphisms in NPAS2 gene and cancer risk.
| S-EPMC4509201 | biostudies-literature
Unknown Association of four common SNPs in microRNA polymorphisms with the risk of hepatocellular carcinoma.
| S-EPMC4583951 | biostudies-literature
Unknown Common mitochondrial polymorphisms as risk factor for endometrial cancer.
| S-EPMC2775024 | biostudies-literature
Unknown No evidence that protein truncating variants in BRIP1 are associated with breast cancer risk: implications for gene panel testing.
| S-EPMC4938802 | biostudies-literature
Unknown Analysis of BRIP1 Variants among Korean Patients with BRCA1/2 Mutation-Negative High-Risk Breast Cancer.
| S-EPMC4946366 | biostudies-literature
Unknown The Association between Four Common Polymorphisms in microRNA and Risk of Hepatocellular Carcinoma: An Updated Meta-Analysis.
| S-EPMC10719708 | biostudies-literature
Unknown Tagging single nucleotide polymorphisms in the BRIP1 gene and susceptibility to breast and ovarian cancer.
| S-EPMC1800910 | biostudies-literature