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Blood flow regulation and oxidative stress during submaximal cycling exercise in patients with cystic fibrosis.

ABSTRACT: BACKGROUND:The impact of blood flow regulation and oxidative stress during exercise in cystic fibrosis (CF) has yet to be investigated. METHODS:A maximal graded exercise test was conducted to determine exercise capacity (VO2 peak) and peak workload in 14 pediatric patients with mild CF (age 14±3y, FEV1 93±16 % predicted) and 14 demographically-matched controls. On a separate visit, participants performed submaximal cycling up to 60% of peak workload where brachial artery blood velocity was determined using Doppler ultrasound. Retrograde and antegrade components were further analyzed as indices of blood flow regulation. RESULTS:The cumulative AUC for retrograde velocity was lower in patients versus controls (1770±554 vs. 3440±522cm, P=0.038). In addition, an exaggerated oxidative stress response during exercise occurred in patients only (P=0.004). CONCLUSION:These data suggest that patients with mild CF exhibit impaired blood flow regulation and an exaggerated oxidative stress response to submaximal exercise.

SUBMITTER: Tucker MA 

PROVIDER: S-EPMC5843503 | biostudies-literature | 2018 Mar

REPOSITORIES: biostudies-literature

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Blood flow regulation and oxidative stress during submaximal cycling exercise in patients with cystic fibrosis.

Tucker Matthew A MA   Berry Breana B   Seigler Nichole N   Davison Gareth W GW   Quindry John C JC   Eidson Dabney D   McKie Kathleen T KT   Harris Ryan A RA  

Journal of cystic fibrosis : official journal of the European Cystic Fibrosis Society 20171012 2

<h4>Background</h4>The impact of blood flow regulation and oxidative stress during exercise in cystic fibrosis (CF) has yet to be investigated.<h4>Methods</h4>A maximal graded exercise test was conducted to determine exercise capacity (VO<sub>2</sub> peak) and peak workload in 14 pediatric patients with mild CF (age 14±3y, FEV<sub>1</sub> 93±16 % predicted) and 14 demographically-matched controls. On a separate visit, participants performed submaximal cycling up to 60% of peak workload where bra  ...[more]

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