Ontology highlight
ABSTRACT: Purpose
Dynamic exercise results in increased systolic blood pressure (BP). Irrespective of resting BP, some individuals may experience exaggerated rise in systolic BP with exercise, which in adulthood is associated with risk of hypertension, and cardiovascular (CV) disease. It is unknown if exercise BP is associated with markers of CV structure during adolescence. We examined this question in a large adolescent cohort taking account of the possible confounding effect of body composition and BP status.Methods
4036 adolescents (mean age 17.8?±?0.4?years, 45% male), part of a UK population-based birth cohort study completed a sub-maximal step-test with BP immediately post-exercise. Sub-samples underwent comprehensive echocardiography for assessment of cardiac structure; arterial structure including aortic pulse wave velocity (PWV) and carotid intima-media thickness; and assessment of body composition by dual-energy X-ray absorptiometry (DXA).Results
Each 5?mm?Hg higher post-exercise systolic BP was associated with CV structure, including 0.38?g/m2.7 (95% CI: 0.29, 0.47) greater left-ventricular mass index (LVMI), and 0.04?m/s (95% CI: 0.03, 0.04) greater aortic PWV. Adjustment for age, total body fat, lean mass and BP status attenuated, but did not abolish associations with LVMI (0.14?g/m2.7 per 5?mm?Hg of post-exercise systolic BP; 95% CI 0.21, 0.39) or aortic PWV (0.03?m/s per 5?mm?Hg of post-exercise systolic BP; 95% CI: 0.02, 0.04).Conclusion
Submaximal exercise systolic BP is associated with markers of CV structure in adolescents. Given the clinical relevance of exercise BP in adulthood, such associations may have implications for CV disease screening in young people and risk in later life.
SUBMITTER: Schultz MG
PROVIDER: S-EPMC6282652 | biostudies-literature | 2019 Jan
REPOSITORIES: biostudies-literature
Schultz Martin G MG Park Chloe C Fraser Abigail A Howe Laura D LD Jones Siana S Rapala Alicja A Davey Smith George G Sharman James E JE Lawlor Deborah A DA Chaturvedi Nish N Deanfield John J Hughes Alun D AD
International journal of cardiology 20181019
<h4>Purpose</h4>Dynamic exercise results in increased systolic blood pressure (BP). Irrespective of resting BP, some individuals may experience exaggerated rise in systolic BP with exercise, which in adulthood is associated with risk of hypertension, and cardiovascular (CV) disease. It is unknown if exercise BP is associated with markers of CV structure during adolescence. We examined this question in a large adolescent cohort taking account of the possible confounding effect of body composition ...[more]