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Arylation of Azaarylmethylamines with Aryl Chlorides and a NiBr2/NIXANTPHOS-based Catalyst.

ABSTRACT: A nickel-catalyzed coupling of azaarylmethylamines with aryl chlorides has been achieved. NIXANTPHOS together with low cost NiBr2 was successfully developed and optimized to exhibit high reactivity at 2.5 mol % loading. Under optimized reaction conditions, aryl(azaaryl)methylamine products were afforded in good to excellent yields (22 examples, up to 98% yield).

SUBMITTER: Gao G

PROVIDER: S-EPMC5844573 | biostudies-literature | 2017 Aug

REPOSITORIES: biostudies-literature

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Arylation of Azaarylmethylamines with Aryl Chlorides and a NiBr<sub>2</sub>/NIXANTPHOS-based Catalyst.

Gao Gui G Fu Yue Y Li Minyan M Wang Bo B Zheng Bing B Hou Shicong S Walsh Patrick J PJ

Advanced synthesis & catalysis 20170712 16

A nickel-catalyzed coupling of azaarylmethylamines with aryl chlorides has been achieved. NIXANTPHOS together with low cost NiBr<sub>2</sub> was successfully developed and optimized to exhibit high reactivity at 2.5 mol % loading. Under optimized reaction conditions, aryl(azaaryl)methylamine products were afforded in good to excellent yields (22 examples, up to 98% yield). ...[more]

PMID: 29531521

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