Ontology highlight
ABSTRACT:
SUBMITTER: Gilchrist JJ
PROVIDER: S-EPMC5844948 | biostudies-literature | 2018 Mar
REPOSITORIES: biostudies-literature
Gilchrist James J JJ Rautanen Anna A Fairfax Benjamin P BP Mills Tara C TC Naranbhai Vivek V Trochet Holly H Pirinen Matti M Muthumbi Esther E Mwarumba Salim S Njuguna Patricia P Mturi Neema N Msefula Chisomo L CL Gondwe Esther N EN MacLennan Jenny M JM Chapman Stephen J SJ Molyneux Malcolm E ME Knight Julian C JC Spencer Chris C A CCA Williams Thomas N TN MacLennan Calman A CA Scott J Anthony G JAG Hill Adrian V S AVS
Nature communications 20180309 1
Nontyphoidal Salmonella (NTS) is a major cause of bacteraemia in Africa. The disease typically affects HIV-infected individuals and young children, causing substantial morbidity and mortality. Here we present a genome-wide association study (180 cases, 2677 controls) and replication analysis of NTS bacteraemia in Kenyan and Malawian children. We identify a locus in STAT4, rs13390936, associated with NTS bacteraemia. rs13390936 is a context-specific expression quantitative trait locus for STAT4 R ...[more]