Ontology highlight
ABSTRACT:
SUBMITTER: Lee SWL
PROVIDER: S-EPMC5845585 | biostudies-literature | 2018
REPOSITORIES: biostudies-literature
Lee Sharon Wei Ling SWL Adriani Giulia G Ceccarello Erica E Pavesi Andrea A Tan Anthony Tanoto AT Bertoletti Antonio A Kamm Roger Dale RD Wong Siew Cheng SC
Frontiers in immunology 20180306
In the hepatitis B virus (HBV)-related hepatocellular carcinoma tumor microenvironment (TME), monocytes reportedly impede natural T cell functions <i>via</i> PD-L1/PD-1 signaling. However, it remains unclear if T cell receptor-redirected T cells (TCR T cells) are similarly inhibited. Hence, we developed a 3D intrahepatic TME microfluidic model to investigate the immunosuppressive potential of monocytes toward HBV-specific TCR T cells and the role of PD-L1/PD-1 signaling. Interestingly, in our 3D ...[more]