Adiponectin stimulates lipid metabolism via AMPK in rabbit blastocysts.
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ABSTRACT:
SUBMITTER: Schindler M
PROVIDER: S-EPMC5850832 | biostudies-literature | 2017 Jul
REPOSITORIES: biostudies-literature
Publications
Adiponectin stimulates lipid metabolism via AMPK in rabbit blastocysts.
Schindler Maria M Pendzialek Mareike M Grybel Katarzyna Joanna KJ Seeling Tom T Gürke Jacqueline J Fischer Bernd B Navarrete Santos Anne A
Human reproduction (Oxford, England) 20170701 7
<h4>Study question</h4>How does a maternal diabetic hyperadiponectineamia affect signal transduction and lipid metabolism in rabbit preimplantation blastocysts?<h4>Summary answer</h4>In a diabetic pregnancy increased levels of adiponectin led to a switch in embryonic metabolism towards a fatty acid-dependent energy metabolism, mainly affecting genes that are responsible for fatty acid uptake and turnover.<h4>What is known already</h4>Although studies in cell culture experiments have shown that a ...[more]
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