Dataset Information

Prospective association between handgrip strength and cardiac structure and function in UK adults.

ABSTRACT:

Background

Handgrip strength, a measure of muscular fitness, is associated with cardiovascular (CV) events and CV mortality but its association with cardiac structure and function is unknown. The goal of this study was to determine if handgrip strength is associated with changes in cardiac structure and function in UK adults.

Methods and results

Left ventricular (LV) ejection fraction (EF), end-diastolic volume (EDV), end-systolic volume (ESV), stroke volume (SV), mass (M), and mass-to-volume ratio (MVR) were measured in a sample of 4,654 participants of the UK Biobank Study 6.3 ± 1 years after baseline using cardiovascular magnetic resonance (CMR). Handgrip strength was measured at baseline and at the imaging follow-up examination. We determined the association between handgrip strength at baseline as well as its change over time and each of the cardiac outcome parameters. After adjustment, higher level of handgrip strength at baseline was associated with higher LVEDV (difference per SD increase in handgrip strength: 1.3ml, 95% CI 0.1-2.4; p = 0.034), higher LVSV (1.0ml, 0.3-1.8; p = 0.006), lower LVM (-1.0g, -1.8 --0.3; p = 0.007), and lower LVMVR (-0.013g/ml, -0.018 --0.007; p<0.001). The association between handgrip strength and LVEDV and LVSV was strongest among younger individuals, while the association with LVM and LVMVR was strongest among older individuals.

Conclusions

Better handgrip strength was associated with cardiac structure and function in a pattern indicative of less cardiac hypertrophy and remodeling. These characteristics are known to be associated with a lower risk of cardiovascular events.

SUBMITTER: Beyer SE

PROVIDER: S-EPMC5851546 | biostudies-literature | 2018

REPOSITORIES: biostudies-literature

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Publications

Prospective association between handgrip strength and cardiac structure and function in UK adults.

Beyer Sebastian E SE Sanghvi Mihir M MM Aung Nay N Hosking Alice A Cooper Jackie A JA Paiva José Miguel JM Lee Aaron M AM Fung Kenneth K Lukaschuk Elena E Carapella Valentina V Mittleman Murray A MA Brage Soren S Piechnik Stefan K SK Neubauer Stefan S Petersen Steffen E SE

PloS one 20180314 3

<h4>Background</h4>Handgrip strength, a measure of muscular fitness, is associated with cardiovascular (CV) events and CV mortality but its association with cardiac structure and function is unknown. The goal of this study was to determine if handgrip strength is associated with changes in cardiac structure and function in UK adults.<h4>Methods and results</h4>Left ventricular (LV) ejection fraction (EF), end-diastolic volume (EDV), end-systolic volume (ESV), stroke volume (SV), mass (M), and ma ...[more]

PMID: 29538386

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Project description:BackgroundThe handgrip strength is a practical, valid, reliable, low-cost tool that presents strong correlations with several health conditions. However, handgrip strength may be inaccurate to prospectively predict the variability of muscular function since the decrease in muscular strength over the years varies according to a muscular group or between upper and lower limbs. Our hypothesis is that the handgrip strength cannot explain the variance of muscle function prospectively.PurposeThe aim of this study was to evaluate the cross-sectional and prospective association between handgrip strength and isokinetic muscle function of the knee and elbow in 780 asymptomatic adults.MethodsIn a sample of 780 adults, we obtained handgrip strength and elbow and knee muscle function (for both flexion and extension at 60°/s and 300°/s) using, respectively, a hydraulic dynamometer and an isokinetic dynamometer. In a cross-sectional analysis, we analyzed the data obtained from baseline assessment. Then, we calculated the absolute change as a result of the variation data between the baseline and the 1-year follow-up assessment of each participant. The correlations were analyzed using Pearson or Spearman coefficients. We used multivariate models to investigate the association between handgrip strength and isokinetic muscle function.Results and discussionThe cross-sectional correlations were significantly moderate-to-strong (r = 0.41-0.71, p < 0.01), but became weak-to-moderate (r = 0.26-0.34, p < 0.01) prospectively. In the cross-sectional analysis, the handgrip strength was selected as a strong predictor for isokinetic variables (∆R 2 = 0.171-0.583, p < 0.05) as expected. Although handgrip strength was also selected as a significant predictor in prospective analysis, it explained only a little variance in isokinetic muscle function of the knee (∆R 2 = 0.7-0.117, p < 0.05). Regarding the predictive models for the elbow, handgrip strength was not selected prospectively.ConclusionThe 1-year absolute change of the handgrip strength cannot explain the variance of the isokinetic muscle function. Thus, specific measures are required for assessing muscle function in epidemiological studies.

Dataset Information

Prospective association between handgrip strength and cardiac structure and function in UK adults.

Background

Methods and results

Conclusions

Publications

Prospective association between handgrip strength and cardiac structure and function in UK adults.

Similar Datasets

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