Ontology highlight
ABSTRACT:
SUBMITTER: Araujo LF
PROVIDER: S-EPMC6155108 | biostudies-literature | 2018 Sep
REPOSITORIES: biostudies-literature
Araujo L F LF Siena A D D ADD Plaça J R JR Brotto D B DB Barros I I II Muys B R BR Biagi C A O CAO Peronni K C KC Sousa J F JF Molfetta G A GA West L C LC West A P AP Leopoldino A M AM Espreafico E M EM Silva W A WA
Scientific reports 20180921 1
Mitochondria are central key players in cell metabolism, and mitochondrial DNA (mtDNA) instability has been linked to metabolic changes that contribute to tumorigenesis and to increased expression of pro-tumorigenic genes. Here, we use melanoma cell lines and metastatic melanoma tumors to evaluate the effect of mtDNA alterations and the expression of the mtDNA packaging factor, TFAM, on energetic metabolism and pro-tumorigenic nuclear gene expression changes. We report a positive correlation bet ...[more]