Ontology highlight
ABSTRACT:
SUBMITTER: Shashar M
PROVIDER: S-EPMC5854487 | biostudies-literature | 2017 Nov
REPOSITORIES: biostudies-literature
Shashar Moshe M Belghasem Mostafa E ME Matsuura Shinobu S Walker Joshua J Richards Sean S Alousi Faisal F Rijal Keshab K Kolachalama Vijaya B VB Balcells Mercedes M Odagi Minami M Nagasawa Kazuo K Henderson Joel M JM Gautam Amitabh A Rushmore Richard R Francis Jean J Kirchhofer Daniel D Kolandaivelu Kumaran K Sherr David H DH Edelman Elazer R ER Ravid Katya K Chitalia Vipul C VC
Science translational medicine 20171101 417
Chronic kidney disease (CKD/uremia) remains vexing because it increases the risk of atherothrombosis and is also associated with bleeding complications on standard antithrombotic/antiplatelet therapies. Although the associations of indolic uremic solutes and vascular wall proteins [such as tissue factor (TF) and aryl hydrocarbon receptor (AHR)] are being defined, the specific mechanisms that drive the thrombotic and bleeding risks are not fully understood. We now present an indolic solute-specif ...[more]