Ontology highlight
ABSTRACT:
SUBMITTER: Croessmann S
PROVIDER: S-EPMC5856622 | biostudies-literature | 2018 Mar
REPOSITORIES: biostudies-literature
Croessmann Sarah S Sheehan Jonathan H JH Lee Kyung-Min KM Sliwoski Gregory G He Jie J Nagy Rebecca R Riddle David D Mayer Ingrid A IA Balko Justin M JM Lanman Richard R Miller Vincent A VA Cantley Lewis C LC Meiler Jens J Arteaga Carlos L CL
Clinical cancer research : an official journal of the American Association for Cancer Research 20171228 6
<b>Purpose:</b> We describe herein a novel P447_L455 deletion in the C2 domain of <i>PIK3CA</i> in a patient with an ER<sup>+</sup> breast cancer with an excellent response to the PI3Kα inhibitor alpelisib. Although <i>PIK3CA</i> deletions are relatively rare, a significant portion of deletions cluster within amino acids 446-460 of the C2 domain, suggesting these residues are critical for p110α function.<b>Experimental Design:</b> A computational structural model of <i>PIK3CA</i><sup>delP447-L45 ...[more]