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Methods for the Synthesis of Functionalized Pentacarboxycyclopentadienes.

ABSTRACT: Protocols for the synthesis of diverse pentacarboxycyclopentadienes are described. Starting from readily available pentacarbomethoxycyclopentadiene, transesterification offers single-step access to aliphatic ester derivatives, while treatment with amines produces mono- or diamides. For less nucleophilic alcohols, an alternative procedure involving the in situ generation and esterification of a putative cyclopentadiene pentaacid chloride has been developed.

SUBMITTER: Gheewala CD

PROVIDER: S-EPMC5859554 | biostudies-literature | 2017 Aug

REPOSITORIES: biostudies-literature

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Methods for the Synthesis of Functionalized Pentacarboxycyclopentadienes.

Gheewala Chirag D CD Radtke M Alex MA Hui Jessica J Hon Alec B AB Lambert Tristan H TH

Organic letters 20170803 16

Protocols for the synthesis of diverse pentacarboxycyclopentadienes are described. Starting from readily available pentacarbomethoxycyclopentadiene, transesterification offers single-step access to aliphatic ester derivatives, while treatment with amines produces mono- or diamides. For less nucleophilic alcohols, an alternative procedure involving the in situ generation and esterification of a putative cyclopentadiene pentaacid chloride has been developed. ...[more]

PMID: 28771371

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