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Synthesis of Functionalized Cannabilactones.

ABSTRACT: A new approach to synthesize cannabilactones using Suzuki cross-coupling reaction followed by one-step demethylation-cyclization is presented. The two key cannabilactone prototypes AM1710 and AM1714 were obtained selectively in high overall yields and in a lesser number of synthetic steps when compared to our earlier synthesis. The new approach expedited the synthesis of cannabilactone analogs with structural modifications at the four potential pharmacophoric regions.

SUBMITTER: Liu Y

PROVIDER: S-EPMC7037859 | biostudies-literature | 2020 Feb

REPOSITORIES: biostudies-literature

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Synthesis of Functionalized Cannabilactones.

Liu Yingpeng Y Ho Thanh C TC Baradwan Mohammed M Pascual Lopez-Alberca Maria M Iliopoulos-Tsoutsouvas Christos C Nikas Spyros P SP Makriyannis Alexandros A

Molecules (Basel, Switzerland) 20200206 3

A new approach to synthesize cannabilactones using Suzuki cross-coupling reaction followed by one-step demethylation-cyclization is presented. The two key cannabilactone prototypes AM1710 and AM1714 were obtained selectively in high overall yields and in a lesser number of synthetic steps when compared to our earlier synthesis. The new approach expedited the synthesis of cannabilactone analogs with structural modifications at the four potential pharmacophoric regions. ...[more]

PMID: 32041131

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