Ontology highlight
ABSTRACT:
SUBMITTER: Liu Y
PROVIDER: S-EPMC7037859 | biostudies-literature | 2020 Feb
REPOSITORIES: biostudies-literature
Liu Yingpeng Y Ho Thanh C TC Baradwan Mohammed M Pascual Lopez-Alberca Maria M Iliopoulos-Tsoutsouvas Christos C Nikas Spyros P SP Makriyannis Alexandros A
Molecules (Basel, Switzerland) 20200206 3
A new approach to synthesize cannabilactones using Suzuki cross-coupling reaction followed by one-step demethylation-cyclization is presented. The two key cannabilactone prototypes AM1710 and AM1714 were obtained selectively in high overall yields and in a lesser number of synthetic steps when compared to our earlier synthesis. The new approach expedited the synthesis of cannabilactone analogs with structural modifications at the four potential pharmacophoric regions. ...[more]