Ontology highlight
ABSTRACT:
SUBMITTER: Becker NA
PROVIDER: S-EPMC5861415 | biostudies-literature | 2018 Mar
REPOSITORIES: biostudies-literature
Becker Nicole A NA Schwab Tanya L TL Clark Karl J KJ Maher L James LJ
Nucleic acids research 20180301 5
Genetic switches must alternate between states whose probabilities are dependent on regulatory signals. Classical examples of transcriptional control in bacteria depend on repressive DNA loops anchored by proteins whose structures are sensitive to small molecule inducers or co-repressors. We are interested in exploiting these natural principles to engineer artificial switches for transcriptional control of bacterial genes. Here, we implement designed homodimeric DNA looping proteins ('Transcript ...[more]