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Immunotherapy for Merkel cell carcinoma: a turning point in patient care.

ABSTRACT: Merkel Cell carcinoma (MCC) is a rare but aggressive cancer, with an estimated disease-associated mortality as high as 46%. MCC has proven to be an immunologically responsive disease and the advent of immune checkpoint inhibitors has changed the treatment landscape for patients with advanced MCC. In this review, we discuss the rationale for the use of immune checkpoint inhibition, review current single agent therapies tested in and approved for MCC, and discuss emerging immunotherapeutic options for these patients.

SUBMITTER: Chan IS 

PROVIDER: S-EPMC5865292 | biostudies-literature | 2018 Mar

REPOSITORIES: biostudies-literature

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Immunotherapy for Merkel cell carcinoma: a turning point in patient care.

Chan Isaac S IS   Bhatia Shailender S   Kaufman Howard L HL   Lipson Evan J EJ  

Journal for immunotherapy of cancer 20180323 1

Merkel Cell carcinoma (MCC) is a rare but aggressive cancer, with an estimated disease-associated mortality as high as 46%. MCC has proven to be an immunologically responsive disease and the advent of immune checkpoint inhibitors has changed the treatment landscape for patients with advanced MCC. In this review, we discuss the rationale for the use of immune checkpoint inhibition, review current single agent therapies tested in and approved for MCC, and discuss emerging immunotherapeutic options  ...[more]

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