Ontology highlight
ABSTRACT:
SUBMITTER: Wilson TA
PROVIDER: S-EPMC5866229 | biostudies-literature | 2018 Mar
REPOSITORIES: biostudies-literature
Journal of natural products 20180205 3
The human 20S proteasome inhibitor scytonemide A (1), a macrocyclic imine originally isolated from the cyanobacterium Scytonema hofmanni, was synthesized via a biomimetic solid-phase peptide synthesis (SPPS) approach employing the Weinreb AM resin. Utilizing this approach, cyclization of the protected heptapeptide via formation of the imine bond occurred spontaneously upon cleavage from the resin in the presence of a reducing agent and subsequent aqueous workup. The final deprotection step neces ...[more]