Dataset Information

How cognitive and reactive fear circuits optimize escape decisions in humans.

ABSTRACT: Flight initiation distance (FID), the distance at which an organism flees from an approaching threat, is an ecological metric of cost-benefit functions of escape decisions. We adapted the FID paradigm to investigate how fast- or slow-attacking "virtual predators" constrain escape decisions. We show that rapid escape decisions rely on "reactive fear" circuits in the periaqueductal gray and midcingulate cortex (MCC), while protracted escape decisions, defined by larger buffer zones, were associated with "cognitive fear" circuits, which include posterior cingulate cortex, hippocampus, and the ventromedial prefrontal cortex, circuits implicated in more complex information processing, cognitive avoidance strategies, and behavioral flexibility. Using a Bayesian decision-making model, we further show that optimization of escape decisions under rapid flight were localized to the MCC, a region involved in adaptive motor control, while the hippocampus is implicated in optimizing decisions that update and control slower escape initiation. These results demonstrate an unexplored link between defensive survival circuits and their role in adaptive escape decisions.

SUBMITTER: Qi S

PROVIDER: S-EPMC5866541 | biostudies-literature | 2018 Mar

REPOSITORIES: biostudies-literature

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Publications

How cognitive and reactive fear circuits optimize escape decisions in humans.

Qi Song S Hassabis Demis D Sun Jiayin J Guo Fangjian F Daw Nathaniel N Mobbs Dean D

Proceedings of the National Academy of Sciences of the United States of America 20180305 12

Flight initiation distance (FID), the distance at which an organism flees from an approaching threat, is an ecological metric of cost-benefit functions of escape decisions. We adapted the FID paradigm to investigate how fast- or slow-attacking "virtual predators" constrain escape decisions. We show that rapid escape decisions rely on "reactive fear" circuits in the periaqueductal gray and midcingulate cortex (MCC), while protracted escape decisions, defined by larger buffer zones, were associate ...[more]

PMID: 29507207

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Project description:How humans resolve non-trivial tradeoffs in their navigational choices between the social interactions (e.g., the presence and movements of others) and the physical factors (e.g., spatial distances, route visibility) when escaping from threats in crowded confined spaces? The answer to this question has major implications for the planning of evacuations and the safety of mass gatherings as well as the design of built environments. Due to the challenges of collecting behavioral data from naturally-occurring evacuation settings, laboratory-based virtual-evacuation experiments have been practiced in a number of studies. This class of experiments faces the traditional question of contextual bias and generalizability: How reliably can we infer humans' behavior from decisions made in hypothetical settings? Here, we address these questions by making a novel link between two different forms of empirical observations. We conduct hypothetical emergency exit-choice experiments framed as simple pictures, and then mimic those hypothetical scenarios in more realistic fashions through staging mock evacuation trials with actual crowds. Econometric choice models are estimated based on the observations made in both experimental contexts. The models are contrasted with each other from a number of perspectives including their predictions as well as the sign, magnitude, statistical significance, person-to-person variations (reflecting individuals' perception/preference differences) and the scale (reflecting context-dependent decision randomness) of their inferred parameters. Results reveal a surprising degree of resemblance between the models derived from the two contexts. Most strikingly, they produce fairly similar prediction probabilities whose differences average less than 10%. There is also unexpected consensus between the inferences derived from both experimental sources on many aspects of people's behavior notably in terms of the perception of social interactions. Results show that we could have elicited peoples' escape strategies with fair precision without observing them in action (i.e., simply by using only hypothetical-choice data as an inexpensive, practical and non-invasive experimental technique in this context). As a broader application, this offers promising evidence as to the potential applicability of the hypothetical-decision experiments to other decision contexts (at least for non-financial decisions) when field or real-world data is prohibitively unavailable. As a practical application, the behavioral insights inferred from our observations (reflected in the estimated parameters) can improve how accurately we predict the movement patterns of human crowds in emergency scenarios arisen in complex spaces. Fully-generic-in-parameters, our proposed models can even be directly introduced to a broad range of crowd simulation software to replicate navigation decision making of evacuees.

Dataset Information

How cognitive and reactive fear circuits optimize escape decisions in humans.

Publications

How cognitive and reactive fear circuits optimize escape decisions in humans.

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