Ontology highlight
ABSTRACT:
SUBMITTER: Piatkevich KD
PROVIDER: S-EPMC5866759 | biostudies-literature | 2018 Apr
REPOSITORIES: biostudies-literature
Nature chemical biology 20180226 4
We developed a new way to engineer complex proteins toward multidimensional specifications using a simple, yet scalable, directed evolution strategy. By robotically picking mammalian cells that were identified, under a microscope, as expressing proteins that simultaneously exhibit several specific properties, we can screen hundreds of thousands of proteins in a library in just a few hours, evaluating each along multiple performance axes. To demonstrate the power of this approach, we created a ge ...[more]