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Honokiol-Inspired Analogs as Inhibitors of Oral Bacteria.

ABSTRACT: The oral microbiome is a complex ecological niche where both commensal and pathogenic bacteria coexist. Previous reports have cited that the plant isolate honokiol is a potent inhibitor of S. mutans biofilms. Herein we report a cross-coupling method that provides access to a concise library of honokiol-inspired analogs. Through this work we determined that the inhibitory activity of honokiol is highly dependent on the growth conditions. Further, we identify a series of analogs that display significant potency against oral bacteria leading to the discovery of a potent antimicrobial.

SUBMITTER: Solinski AE

PROVIDER: S-EPMC5869685 | biostudies-literature | 2018 Feb

REPOSITORIES: biostudies-literature

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Honokiol-Inspired Analogs as Inhibitors of Oral Bacteria.

Solinski Amy E AE Ochoa Cristian C Lee Young Eun YE Paniak Thomas T Kozlowski Marisa C MC Wuest William M WM

ACS infectious diseases 20171213 2

The oral microbiome is a complex ecological niche where both commensal and pathogenic bacteria coexist. Previous reports have cited that the plant isolate honokiol is a potent inhibitor of S. mutans biofilms. Herein we report a cross-coupling method that provides access to a concise library of honokiol-inspired analogs. Through this work we determined that the inhibitory activity of honokiol is highly dependent on the growth conditions. Further, we identify a series of analogs that display signi ...[more]

PMID: 29236466

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Project description:oral bacteria Raw sequence reads

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