Ontology highlight
ABSTRACT:
SUBMITTER: Bender CF
PROVIDER: S-EPMC5983035 | biostudies-literature | 2018 Mar
REPOSITORIES: biostudies-literature
Tetrahedron 20180112 9
We describe a complete account of our total synthesis and biological evaluation of (-)-berkelic acid and analogs. We delineate a synthetic strategy inspired by a potentially biomimetic union between the natural products spicifernin and pulvilloric acid. After defining optimal parameters, we executed a one-pot silver-mediated in situ dehydration of an isochroman lactol to methyl pulvillorate, the cycloisomerization of a spicifernin-like alkynol to the corresponding exocyclic enol ether, and a sub ...[more]