Clinical and radiographic response following targeting of BCAN-NTRK1 fusion in glioneuronal tumor.

ABSTRACT: Glioneuronal tumors constitute a histologically diverse group of primary central nervous system neoplasms that are typically slow-growing and managed conservatively. Genetic alterations associated with glioneuronal tumors include BRAF mutations and oncogenic fusions. To further characterize this group of tumors, we collected a cohort of 26 glioneuronal tumors and performed in-depth genomic analysis. We identified mutations in BRAF (34%) and oncogenic fusions (30%), consistent with previously published reports. In addition, we discovered novel oncogenic fusions involving members of the NTRK gene family in a subset of our cohort. One-patient with BCAN exon 13 fused to NTRK1 exon 11 initially underwent a subtotal resection for a 4th ventricular glioneuronal tumor but ultimately required addit

SUBMITTER: Alvarez-Breckenridge C 

PROVIDER: S-EPMC5871889 | biostudies-literature | 2017

REPOSITORIES: biostudies-literature