Ontology highlight
ABSTRACT:
SUBMITTER: Jimenez JC
PROVIDER: S-EPMC5877404 | biostudies-literature | 2018 Feb
REPOSITORIES: biostudies-literature
Jimenez Jessica C JC Su Katy K Goldberg Alexander R AR Luna Victor M VM Biane Jeremy S JS Ordek Gokhan G Zhou Pengcheng P Ong Samantha K SK Wright Matthew A MA Zweifel Larry L Paninski Liam L Hen René R Kheirbek Mazen A MA
Neuron 20180131 3
The hippocampus is traditionally thought to transmit contextual information to limbic structures where it acquires valence. Using freely moving calcium imaging and optogenetics, we show that while the dorsal CA1 subregion of the hippocampus is enriched in place cells, ventral CA1 (vCA1) is enriched in anxiety cells that are activated by anxiogenic environments and required for avoidance behavior. Imaging cells defined by their projection target revealed that anxiety cells were enriched in the vC ...[more]