Ontology highlight
ABSTRACT:
SUBMITTER: Serra H
PROVIDER: S-EPMC5877939 | biostudies-literature | 2018 Mar
REPOSITORIES: biostudies-literature
Serra Heïdi H Lambing Christophe C Griffin Catherine H CH Topp Stephanie D SD Nageswaran Divyashree C DC Underwood Charles J CJ Ziolkowski Piotr A PA Séguéla-Arnaud Mathilde M Fernandes Joiselle B JB Mercier Raphaël R Henderson Ian R IR
Proceedings of the National Academy of Sciences of the United States of America 20180220 10
During meiosis, homologous chromosomes undergo reciprocal crossovers, which generate genetic diversity and underpin classical crop improvement. Meiotic recombination initiates from DNA double-strand breaks (DSBs), which are processed into single-stranded DNA that can invade a homologous chromosome. The resulting joint molecules can ultimately be resolved as crossovers. In <i>Arabidopsis</i>, competing pathways balance the repair of ∼100-200 meiotic DSBs into ∼10 crossovers per meiosis, with the ...[more]