Ontology highlight
ABSTRACT:
SUBMITTER: Banerjee R
PROVIDER: S-EPMC5879666 | biostudies-literature | 2018 Mar
REPOSITORIES: biostudies-literature
Banerjee Rahul R Yoder Jesse B JB Yue David T DT Amzel L Mario LM Tomaselli Gordon F GF Gabelli Sandra B SB Ben-Johny Manu M
Proceedings of the National Academy of Sciences of the United States of America 20180312 13
Calmodulin (CaM) regulation of voltage-gated calcium (Ca<sub>V</sub>) channels is a powerful Ca<sup>2+</sup> feedback mechanism that adjusts Ca<sup>2+</sup> influx, affording rich mechanistic insights into Ca<sup>2+</sup> decoding. CaM possesses a dual-lobed architecture, a salient feature of the myriad Ca<sup>2+</sup>-sensing proteins, where two homologous lobes that recognize similar targets hint at redundant signaling mechanisms. Here, by tethering CaM lobes, we demonstrate that bilobal archi ...[more]