Ontology highlight
ABSTRACT:
SUBMITTER: St Leger AJ
PROVIDER: S-EPMC5881461 | biostudies-literature | 2018 Apr
REPOSITORIES: biostudies-literature
St Leger Anthony J AJ Hansen Anna M AM Karauzum Hatice H Horai Reiko R Yu Cheng-Rong CR Laurence Arian A Mayer-Barber Katrin D KD Silver Phyllis P Villasmil Rafael R Egwuagu Charles C Datta Sandip K SK Caspi Rachel R RR
The Journal of experimental medicine 20180228 4
Appropriate regulation of IL-17 production in the host can mean the difference between effective control of pathogens and uncontrolled inflammation that causes tissue damage. Investigation of conventional CD4<sup>+</sup> T cells (Th17 cells) has yielded invaluable insights into IL-17 function and its regulation. More recently, we and others reported production of IL-17 from innate αβ+ T cell populations, which was shown to occur primarily via IL-23R signaling through the transcription factor STA ...[more]