Ontology highlight
ABSTRACT:
SUBMITTER: Schmidt S
PROVIDER: S-EPMC5881468 | biostudies-literature | 2018 Apr
REPOSITORIES: biostudies-literature
The Journal of experimental medicine 20180222 4
Colorectal cancer is treated with antibodies blocking epidermal growth factor receptor (EGF-R), but therapeutic success is limited. EGF-R is stimulated by soluble ligands, which are derived from transmembrane precursors by ADAM17-mediated proteolytic cleavage. In mouse intestinal cancer models in the absence of ADAM17, tumorigenesis was almost completely inhibited, and the few remaining tumors were of low-grade dysplasia. RNA sequencing analysis demonstrated down-regulation of STAT3 and Wnt path ...[more]