Ontology highlight
ABSTRACT:
SUBMITTER: Deatherage CL
PROVIDER: S-EPMC4472088 | biostudies-other | 2015 Jun
REPOSITORIES: biostudies-other
Deatherage Catherine L CL Lu Zhenwei Z Kim Ji-Hun JH Sanders Charles R CR
Biochemistry 20150604 23
The Notch signaling pathway is critical in development, neuronal maintenance, and hematopoiesis. An obligate step in the activation of this pathway is cleavage of its transmembrane (TM) domain by γ-secretase. While the soluble domains have been extensively studied, little has been done to characterize its TM and flanking juxtamembrane (JM) segments. Here, we present the results of nuclear magnetic resonance (NMR) studies of the human Notch1 TM/JM domain. The TM domain is largely α-helical. While ...[more]