Recruitment of lysine demethylase 2A to DNA double strand breaks and its interaction with 53BP1 ensures genome stability.
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ABSTRACT:
SUBMITTER: Bueno MTD
PROVIDER: S-EPMC5882307 | biostudies-literature | 2018 Mar
REPOSITORIES: biostudies-literature
Publications
Recruitment of lysine demethylase 2A to DNA double strand breaks and its interaction with 53BP1 ensures genome stability.
Bueno Murilo T D MTD Baldascini Marta M Richard Stéphane S Lowndes Noel F NF
Oncotarget 20180323 22
Lysine demethylase 2A (KDM2A) functions in transcription as a demethylase of lysine 36 on histone H3. Herein, we characterise a role for KDM2A in the DNA damage response in which KDM2A stimulates conjugation of ubiquitin to 53BP1. Impaired KDM2A-mediated ubiquitination negatively affects the recruitment of 53BP1 to DSBs. Notably, we show that KDM2A itself is recruited to DSBs in a process that depends on its demethylase activity and zinc finger domain. Moreover, we show that KDM2A plays an impor ...[more]
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