Detection of DNA Double Strand Breaks by ?H2AX Does Not Result in 53bp1 Recruitment in Mouse Retinal Tissues.
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ABSTRACT:
SUBMITTER: Muller B
PROVIDER: S-EPMC5938408 | biostudies-literature | 2018
REPOSITORIES: biostudies-literature
Publications
Detection of DNA Double Strand Breaks by γH2AX Does Not Result in 53bp1 Recruitment in Mouse Retinal Tissues.
Müller Brigitte B Ellinwood N M NM Lorenz Birgit B Stieger Knut K
Frontiers in neuroscience 20180501
Gene editing is an attractive potential treatment of inherited retinopathies. However, it often relies on endogenous DNA repair. Retinal DNA repair is incompletely characterized in humans and animal models. We investigated recruitment of the double stranded break (DSB) repair complex of γH2AX and 53bp1 in both developing and mature mouse neuroretinas. We evaluated the immunofluorescent retinal expression of these proteins during development (P07-P30) in normal and retinal degeneration models, as ...[more]
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