Ontology highlight
ABSTRACT:
SUBMITTER: Shi T
PROVIDER: S-EPMC5882647 | biostudies-literature | 2018 Apr
REPOSITORIES: biostudies-literature
Shi Tianhui T Wang Menglin M Li Hao H Wang Miao M Luo Xingyu X Huang Yan Y Wang Hong-Hui HH Nie Zhou Z Yao Shouzhuo S
Scientific reports 20180403 1
Cancer cells contain a unique set of cell surface receptors that provide potential targets for tumor theranostics. Here, we propose an efficient approach to construct G-quadruplex-based aptamers that specifically recognize cell-surface receptors and monitor them in an amplified manner. This designed aptamer combined particular sequence for the c-Met on the cell surface and poly-G-quadruplexes structures that allow a rapid and amplified fluorescent readout upon the binding of thioflavin T (ThT). ...[more]