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Meta-analysis of genome-wide association studies identifies 8 novel loci involved in shape variation of human head hair.

ABSTRACT: Shape variation of human head hair shows striking variation within and between human populations, while its genetic basis is far from being understood. We performed a series of genome-wide association studies (GWASs) and replication studies in a total of 28 964 subjects from 9 cohorts from multiple geographic origins. A meta-analysis of three European GWASs identified 8 novel loci (1p36.23 ERRFI1/SLC45A1, 1p36.22 PEX14, 1p36.13 PADI3, 2p13.3 TGFA, 11p14.1 LGR4, 12q13.13 HOXC13, 17q21.2 KRTAP, and 20q13.33 PTK6), and confirmed 4 previously known ones (1q21.3 TCHH/TCHHL1/LCE3E, 2q35 WNT10A, 4q21.21 FRAS1, and 10p14 LINC00708/GATA3), all showing genome-wide significant association with hair shape (P?

SUBMITTER: Liu F 

PROVIDER: S-EPMC5886212 | biostudies-literature | 2018 Feb

REPOSITORIES: biostudies-literature

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Meta-analysis of genome-wide association studies identifies 8 novel loci involved in shape variation of human head hair.

Liu Fan F   Chen Yan Y   Zhu Gu G   Hysi Pirro G PG   Wu Sijie S   Adhikari Kaustubh K   Breslin Krystal K   Pospiech Ewelina E   Hamer Merel A MA   Peng Fuduan F   Muralidharan Charanya C   Acuna-Alonzo Victor V   Canizales-Quinteros Samuel S   Bedoya Gabriel G   Gallo Carla C   Poletti Giovanni G   Rothhammer Francisco F   Bortolini Maria Catira MC   Gonzalez-Jose Rolando R   Zeng Changqing C   Xu Shuhua S   Jin Li L   Uitterlinden André G AG   Ikram M Arfan MA   van Duijn Cornelia M CM   Nijsten Tamar T   Walsh Susan S   Branicki Wojciech W   Wang Sijia S   Ruiz-Linares Andrés A   Spector Timothy D TD   Martin Nicholas G NG   Medland Sarah E SE   Kayser Manfred M  

Human molecular genetics 20180201 3

Shape variation of human head hair shows striking variation within and between human populations, while its genetic basis is far from being understood. We performed a series of genome-wide association studies (GWASs) and replication studies in a total of 28 964 subjects from 9 cohorts from multiple geographic origins. A meta-analysis of three European GWASs identified 8 novel loci (1p36.23 ERRFI1/SLC45A1, 1p36.22 PEX14, 1p36.13 PADI3, 2p13.3 TGFA, 11p14.1 LGR4, 12q13.13 HOXC13, 17q21.2 KRTAP, an  ...[more]

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