Genetic and Epigenetic of Medullary Thyroid Cancer
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ABSTRACT:
SUBMITTER: Khatami F
PROVIDER: S-EPMC5889499 | biostudies-literature | 2018 May
REPOSITORIES: biostudies-literature
Publications
Genetic and Epigenetic of Medullary Thyroid Cancer
Khatami Fatemeh F Tavangar Seyed Mohammad SM
Iranian biomedical journal 20171111 3
Medullary thyroid carcinoma (MTC) is an infrequent, calcitonin producing neuroendocrine tumor and initiates from the parafollicular C cells of the thyroid gland. Several genetic and epigenetic alterations are collaterally responsible for medullary thyroid carcinogenesis. In this review article, we shed light on all the genetic and epigenetic hallmarks of MTC. From the genetic perspective, RET, HRAS, and KRAS are the most important genes that are characterized in MTC. From the epigenetic perspect ...[more]
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