Ontology highlight
ABSTRACT:
SUBMITTER: Mirzamohammadi F
PROVIDER: S-EPMC5893605 | biostudies-literature | 2018 Apr
REPOSITORIES: biostudies-literature
Nature communications 20180410 1
Feingold syndrome is a skeletal dysplasia caused by loss-of-function mutations of either MYCN (type 1) or MIR17HG that encodes miR-17-92 microRNAs (type 2). Since miR-17-92 expression is transcriptionally regulated by MYC transcription factors, it has been postulated that Feingold syndrome type 1 and 2 may be caused by a common molecular mechanism. Here we show that Mir17-92 deficiency upregulates TGF-β signaling, whereas Mycn-deficiency downregulates PI3K signaling in limb mesenchymal cells. Ge ...[more]