GlcNAc Conjugated Atorvastatin with Enhanced Water Solubility and Cellular Internalization.
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ABSTRACT:
SUBMITTER: Zhang X
PROVIDER: S-EPMC5896756 | biostudies-literature | 2017 Aug
REPOSITORIES: biostudies-literature
Publications
GlcNAc Conjugated Atorvastatin with Enhanced Water Solubility and Cellular Internalization.
Zhang Xinfu X Chen Xiaofang X Zhao Weiyu W Zeng Chunxi C Luo Xiao X Li Wenqing W Li Bin B Jiang Justin J Dong Yizhou Y
Bioconjugate chemistry 20170807 8
Targeting ligands facilitate cell specific drug delivery and improve pharmaceutical properties. Herein, we designed two ligand drug conjugates by conjugating GlcNAc (N-acetylglucosamine) with atorvastatin. These two conjugates, termed G-AT and G-K-AT, exhibited enhanced water solubility and cellular uptake. Moreover, both G-AT and G-K-AT were able to release atorvastatin and consequently achieve significant inhibition against 3-hydroxy-3-methyl-glutaryl-coenzyme A (HMG-CoA) reductase. ...[more]
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