Unknown

Dataset Information

0

Pharmaceutical concentration using organic solvent forward osmosis for solvent recovery.


ABSTRACT: The organic solvent forward osmosis (OSFO) process can simultaneously concentrate the active pharmaceutical ingredients (APIs) and recover the organic solvents. Here we demonstrate and evaluate an OSFO process for solvent recovery. In this demonstration, OSFO was conducted in different solvents with different draw solutes. The OSFO process shows rejections >98% when recovering organic solvents from different feed solutions, even when the feed concentration is as high as 20?wt%. More importantly, all systems exhibit relatively low ratios of reverse solute flux to solvent flux, indicating that the adverse effects of using hazardous draw solutions could be minimized. Nevertheless, the use of non-hazardous draw solutes such as citric acid is highly recommended to remove any potential risk, and it has been demonstrated. Herein, the OSFO process is a promising technology for solvent recovery as it possesses a reasonable solvent flux, low reverse solute flux and requires no external pressure.

SUBMITTER: Cui Y 

PROVIDER: S-EPMC5897543 | biostudies-literature | 2018 Apr

REPOSITORIES: biostudies-literature

altmetric image

Publications

Pharmaceutical concentration using organic solvent forward osmosis for solvent recovery.

Cui Yue Y   Chung Tai-Shung TS  

Nature communications 20180412 1


The organic solvent forward osmosis (OSFO) process can simultaneously concentrate the active pharmaceutical ingredients (APIs) and recover the organic solvents. Here we demonstrate and evaluate an OSFO process for solvent recovery. In this demonstration, OSFO was conducted in different solvents with different draw solutes. The OSFO process shows rejections >98% when recovering organic solvents from different feed solutions, even when the feed concentration is as high as 20 wt%. More importantly,  ...[more]

Similar Datasets

| S-EPMC7057969 | biostudies-literature
| S-EPMC8779258 | biostudies-literature
| S-EPMC8401517 | biostudies-literature
| S-EPMC7693741 | biostudies-literature
| S-EPMC8399973 | biostudies-literature
| S-EPMC7823477 | biostudies-literature
| S-EPMC7077303 | biostudies-literature
| S-EPMC8280685 | biostudies-literature
| S-EPMC4726141 | biostudies-other
| S-EPMC6780785 | biostudies-literature