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LncKdm2b controls self-renewal of embryonic stem cells via activating expression of transcription factor Zbtb3.

ABSTRACT: Divergent long noncoding RNAs (lncRNAs) represent a major lncRNA biotype in mouse and human genomes. The biological and molecular functions of the divergent lncRNAs remain largely unknown. Here, we show that lncKdm2b, a divergent lncRNA for Kdm2b gene, is conserved among five mammalian species and highly expressed in embryonic stem cells (ESCs) and early embryos. LncKdm2b knockout impairs ESC self-renewal and causes early embryonic lethality. LncKdm2b can activate Zbtb3 by promoting the assembly and ATPase activity of Snf2-related CREBBP activator protein (SRCAP) complex in trans Zbtb3 potentiates the ESC self-renewal in a Nanog-dependent manner. Finally, Zbtb3 deficiency impairs the ESC self-renewal and early embryonic development. Therefore, our findings reveal that lncRNAs may represent an additional layer of the regulation of ESC self-renewal and early embryogenesis.

SUBMITTER: Ye B 

PROVIDER: S-EPMC5897780 | biostudies-literature | 2018 Apr

REPOSITORIES: biostudies-literature

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<i>LncKdm2b</i> controls self-renewal of embryonic stem cells via activating expression of transcription factor <i>Zbtb3</i>.

Ye Buqing B   Liu Benyu B   Yang Liuliu L   Zhu Xiaoxiao X   Zhang Dongdong D   Wu Wei W   Zhu Pingping P   Wang Yanying Y   Wang Shuo S   Xia Pengyan P   Du Ying Y   Meng Shu S   Huang Guanling G   Wu Jiayi J   Chen Runsheng R   Tian Yong Y   Fan Zusen Z  

The EMBO journal 20180313 8

Divergent long noncoding RNAs (lncRNAs) represent a major lncRNA biotype in mouse and human genomes. The biological and molecular functions of the divergent lncRNAs remain largely unknown. Here, we show that <i>lncKdm2b</i>, a divergent lncRNA for <i>Kdm2b</i> gene, is conserved among five mammalian species and highly expressed in embryonic stem cells (ESCs) and early embryos. <i>LncKdm2b</i> knockout impairs ESC self-renewal and causes early embryonic lethality. <i>LncKdm2b</i> can activate Zbt  ...[more]

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