Ontology highlight
ABSTRACT:
SUBMITTER: Herr AB
PROVIDER: S-EPMC5900751 | biostudies-literature | 2018 Apr
REPOSITORIES: biostudies-literature
The Journal of biological chemistry 20180401 15
Caspase-3 is well known as the "executioner" whose activation commits the cell to an apoptotic fate, but low levels of caspase-3 activity also play key roles in development. A new study explains how cells can balance these functions, using biophysical, structural, and computational approaches to demonstrate the mechanism by which phosphorylation of conserved sites on a distal surface loop reduces or abolishes catalytic activity. These results provide new insights into allosteric regulation mecha ...[more]