Ontology highlight
ABSTRACT:
SUBMITTER: Musette P
PROVIDER: S-EPMC5908887 | biostudies-literature | 2018
REPOSITORIES: biostudies-literature
Musette Philippe P Bouaziz Jean David JD
Frontiers in immunology 20180413
B cells are major effector cells in autoimmunity through antibody production, T cell help and pro-inflammatory cytokine production. Major advances have been made in human B cell biology knowledge using rituximab and type II new anti-CD20 antibodies, anti-CD19 antibodies, anti-CD22 antibodies, autoantigen specific B cell depleting therapy (chimeric antigen receptor T cells), and B cell receptor signaling inhibition (Bruton's tyrosine kinase inhibitors). However, in certain circumstances B cell de ...[more]