Ontology highlight
ABSTRACT:
SUBMITTER: Luo YJ
PROVIDER: S-EPMC5910424 | biostudies-literature | 2018 Apr
REPOSITORIES: biostudies-literature
Luo Yan-Jia YJ Li Ya-Dong YD Wang Lu L Yang Su-Rong SR Yuan Xiang-Shan XS Wang Juan J Cherasse Yoan Y Lazarus Michael M Lazarus Michael M Chen Jiang-Fan JF Qu Wei-Min WM Huang Zhi-Li ZL
Nature communications 20180420 1
Nucleus accumbens (NAc) is involved in behaviors that depend on heightened wakefulness, but its impact on arousal remains unclear. Here, we demonstrate that NAc dopamine D<sub>1</sub> receptor (D<sub>1</sub>R)-expressing neurons are essential for behavioral arousal. Using in vivo fiber photometry in mice, we find arousal-dependent increases in population activity of NAc D<sub>1</sub>R neurons. Optogenetic activation of NAc D<sub>1</sub>R neurons induces immediate transitions from non-rapid eye m ...[more]