High Genetic Plasticity in Multidrug-Resistant Sequence Type 3-IncHI2 Plasmids Revealed by Sequence Comparison and Phylogenetic Analysis.
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ABSTRACT:
SUBMITTER: Fang LX
PROVIDER: S-EPMC5913921 | biostudies-literature | 2018 Apr
REPOSITORIES: biostudies-literature
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High Genetic Plasticity in Multidrug-Resistant Sequence Type 3-IncHI2 Plasmids Revealed by Sequence Comparison and Phylogenetic Analysis.
Fang Liang-Xing LX Li Xing-Ping XP Deng Guo-Hui GH Li Shu-Min SM Yang Run-Shi RS Wu Zuo-Wei ZW Liao Xiao-Ping XP Sun Jian J Liu Ya-Hong YH
Antimicrobial agents and chemotherapy 20180327 4
We report a novel fusion plasmid, pP2-3T, cointegrating sequence type 3 (ST3)-IncHI2 with an IncFII plasmid backbone mediating multidrug resistance (MDR) and virulence. Phylogenetic analysis and comparative genomics revealed that pP2-3T and other MDR ST3-IncHI2 plasmids clustered together, representing a unique IncHI2 lineage that exhibited high conservation in backbones of plasmids but possessed highly genetic plasticity in various regions by acquiring numerous antibiotic resistance genes and f ...[more]
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