Ontology highlight
ABSTRACT:
SUBMITTER: Copeland RA
PROVIDER: S-EPMC5915721 | biostudies-literature | 2018 Jun
REPOSITORIES: biostudies-literature
Philosophical transactions of the Royal Society of London. Series B, Biological sciences 20180601 1748
The protein methyltransferases (PMTs) represent a large class of enzymes that catalyse the methylation of side chain nitrogen atoms of the amino acids lysine or arginine at specific locations along the primary sequence of target proteins. These enzymes play a key role in the spatio-temporal control of gene transcription by performing site-specific methylation of lysine or arginine residues within the histone proteins of chromatin, thus effecting chromatin conformational changes that activate or ...[more]