Ontology highlight
ABSTRACT:
SUBMITTER: Keith F
PROVIDER: S-EPMC3153183 | biostudies-other | 2010 Dec
REPOSITORIES: biostudies-other
Keith Foster F John Chaddock C
Toxins 20101203 12
Botulinum neurotoxins are highly effective therapeutic products. Their therapeutic success results from highly specific and potent inhibition of neurotransmitter release with a duration of action measured in months. These same properties, however, make the botulinum neurotoxins the most potent acute lethal toxins known. Their toxicity and restricted target cell activity severely limits their clinical utility. Understanding the structure-function relationship of the neurotoxins has enabled the de ...[more]