Heterogeneity of SOX9 and HNF1? in Pancreatic Ducts Is Dynamic.
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ABSTRACT:
SUBMITTER: Rezanejad H
PROVIDER: S-EPMC5918495 | biostudies-literature | 2018 Mar
REPOSITORIES: biostudies-literature
Publications
Heterogeneity of SOX9 and HNF1β in Pancreatic Ducts Is Dynamic.
Rezanejad Habib H Ouziel-Yahalom Limor L Keyzer Charlotte A CA Sullivan Brooke A BA Hollister-Lock Jennifer J Li Wan-Chun WC Guo Lili L Deng Shaopeng S Lei Ji J Markmann James J Bonner-Weir Susan S
Stem cell reports 20180301 3
Pancreatic duct epithelial cells have been suggested as a source of progenitors for pancreatic growth and regeneration. However, genetic lineage-tracing experiments with pancreatic duct-specific Cre expression have given conflicting results. Using immunofluorescence and flow cytometry, we show heterogeneous expression of both HNF1β and SOX9 in adult human and murine ductal epithelium. Their expression was dynamic and diminished significantly after induced replication. Purified pancreatic duct ce ...[more]
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