Ontology highlight
ABSTRACT:
SUBMITTER: Todd WD
PROVIDER: S-EPMC5920747 | biostudies-literature | 2018 May
REPOSITORIES: biostudies-literature
Todd William D WD Fenselau Henning H Wang Joshua L JL Zhang Rong R Machado Natalia L NL Venner Anne A Broadhurst Rebecca Y RY Kaur Satvinder S Lynagh Timothy T Olson David P DP Lowell Bradford B BB Fuller Patrick M PM Saper Clifford B CB
Nature neuroscience 20180409 5
'Sundowning' in dementia and Alzheimer's disease is characterized by early-evening agitation and aggression. While such periodicity suggests a circadian origin, whether the circadian clock directly regulates aggressive behavior is unknown. We demonstrate that a daily rhythm in aggression propensity in male mice is gated by GABAergic subparaventricular zone (SPZ<sup>GABA</sup>) neurons, the major postsynaptic targets of the central circadian clock, the suprachiasmatic nucleus. Optogenetic mapping ...[more]