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Recruitment of mitofusin 2 into "lipid rafts" drives mitochondria fusion induced by Mdivi-1.

ABSTRACT: The regulation of the mitochondrial dynamics and the balance between fusion and fission processes are crucial for the health and fate of the cell. Mitochondrial fusion and fission machinery is controlled by key proteins such as mitofusins, OPA-1 and several further molecules. In the present work we investigated the implication of lipid rafts in mitochondrial fusion induced by Mdivi-1. Our results underscore the possible implication of lipid "rafts" in mitochondrial morphogenetic changes and their homeostasis.

SUBMITTER: Ciarlo L

PROVIDER: S-EPMC5922362 | biostudies-literature | 2018 Apr

REPOSITORIES: biostudies-literature

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Recruitment of mitofusin 2 into "lipid rafts" drives mitochondria fusion induced by Mdivi-1.

Ciarlo Laura L Vona Rosa R Manganelli Valeria V Gambardella Lucrezia L Raggi Carla C Marconi Matteo M Malorni Walter W Sorice Maurizio M Garofalo Tina T Matarrese Paola P

Oncotarget 20180410 27

The regulation of the mitochondrial dynamics and the balance between fusion and fission processes are crucial for the health and fate of the cell. Mitochondrial fusion and fission machinery is controlled by key proteins such as mitofusins, OPA-1 and several further molecules. In the present work we investigated the implication of lipid rafts in mitochondrial fusion induced by Mdivi-1. Our results underscore the possible implication of lipid "rafts" in mitochondrial morphogenetic changes and thei ...[more]

PMID: 29721168

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