Ontology highlight
ABSTRACT:
SUBMITTER: Ji J
PROVIDER: S-EPMC5924754 | biostudies-literature | 2018 May
REPOSITORIES: biostudies-literature
Ji Jie J Yin Yin Y Ju Huanyu H Xu Xiaoliang X Liu Wei W Fu Qiang Q Hu Jiaojiao J Zhang Xudong X Sun Beicheng B
Cell death & disease 20180501 5
Although one of the first comprehensive examinations of long non-coding RNA (lncRNA) expression was performed in human CD8 T lymphocytes, little is known about their roles in CD8 T cells functions during the progression of hepatocellular carcinoma (HCC). Here, we show that Lnc-Tim3 is upregulated and negatively correlates with IFN-γ and IL-2 production in tumor-infiltrating CD8 T cells of HCC patients. Lnc-Tim3 plays a pivotal role in stimulating CD8 T exhaustion and the survival of the exhauste ...[more]