Ontology highlight
ABSTRACT:
SUBMITTER: McLelland GL
PROVIDER: S-EPMC5927771 | biostudies-literature | 2018 Apr
REPOSITORIES: biostudies-literature
McLelland Gian-Luca GL Goiran Thomas T Yi Wei W Dorval Geneviève G Chen Carol X CX Lauinger Nadine D ND Krahn Andrea I AI Valimehr Sepideh S Rakovic Aleksandar A Rouiller Isabelle I Durcan Thomas M TM Trempe Jean-François JF Fon Edward A EA
eLife 20180420
Despite their importance as signaling hubs, the function of mitochondria-ER contact sites in mitochondrial quality control pathways remains unexplored. Here we describe a mechanism by which Mfn2, a mitochondria-ER tether, gates the autophagic turnover of mitochondria by PINK1 and parkin. Mitochondria-ER appositions are destroyed during mitophagy, and reducing mitochondria-ER contacts increases the rate of mitochondrial degradation. Mechanistically, parkin/PINK1 catalyze a rapid burst of Mfn2 pho ...[more]